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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- ILB-H5257
- 製品名称
- Human IL-17B Protein, Fc Tag (MALS verified)
- タンパク質名
- IL-17B
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.6 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 95% |
| Description | IL-17B is a member of IL17 famaily, was originally described as a proinflammatory cytokine. IL-17B is produced by neutrophils and potentiates TNF-α effect on the production of cytokines and chemokines, such as IL-6, G-CSF, and CCL20, known to control immune cell trafficking to inflamed tissues. Interestingly, although IL-17B and IL-17E (IL-25) share a common receptor, IL-17RB, IL-17B, and IL-17E deficiency lead to opposite results in a model of acute colitis induced by dextran sulfate sodium. IL-17B inhibits IL-17E binding to IL-17RA? IL-17RB complexes on epithelial cells, and limits IL-17E-induced IL-6 production by colon epithelial cells. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/il-17b-human-ilb-h5257 |
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