Human IL-8 / CXCL8 Protein, premium grade [IL8-H5217]

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Synonyms	-
Characteristics	This protein carries no "tag". The protein has a calculated MW of 8.4 kDa. The protein migrates as 9 kDa±3 kDa under reducing (R) condition, and 11 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	0.01 EU per μg
Purity	95%
Description	Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. There are many receptors on the surface membrane capable of binding IL-8, the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/il-8-human-il8-h5217

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