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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
IL6-H4218
製品名称
ActiveMax Recombinant Human IL-6
タンパク質名
IL-6
Species
Human
HOST
HEK293
20ug: 34,000円
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50ug: 74,000円
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Overview

Synonyms IL6,HGF,Interleukin-6,BSF2,HSF,IFNB2
Characteristics This protein carries no "tag". The protein has a calculated MW of 20.8 kDa. The protein migrates as 24-27 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >98% as determined by SDS-PAGE.
Description Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.
Reference (1) Ferguson-Smith AC,et.al. 1988, Genomics 2 (3): 203?8.
(2) Schwantner A,et. al. 2004, J. Biol. Chem. 279 (1): 571?6.
(3) Schuster B,et. al. 2003, J. Biol. Chem. 278 (11): 9528?35.
(4) Taga T,et al.1989, Cell 58 (3): 573?81.
URL http://www.acrobiosystems.com/P164-Human-IL-6-Interleukin-6-ProteinHEK293-expressedActiveMax.html

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