Mouse IL-12B&IL-12A Heterodimer Protein, Tag Free&His Tag (MALS verified) [IL2-M52W3]

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サプライヤー: AcroBioSystems
カタログNo.: IL2-M52W3
製品名称: Mouse IL-12B&IL-12A Heterodimer Protein, Tag Free&His Tag (MALS verified)
タンパク質名: IL-12B & IL-12A
Species: Mouse
HOST: HEK293

Synonyms	-
Characteristics	Mouse IL-12B&IL-12A Heterodimer Protein, Tag Free&His Tag, produced by co-expression of IL-12B and IL-12A, has a calculated MW of 35.8 kDa (IL-12B) and 23.6 kDa (IL-12A). Subunit IL-12B is no tag and subunit IL-12A contains a polyhistidine tag at the C-terminus. The protein migrates as 28-30 kDa, 42-43 kDa and 45-46 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/il-12b-il-12a-mouse-il2-m52w3

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