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- サプライヤー
- AcroBioSystems
- カタログNo.
- IL2-H5213
- 製品名称
- Human IL-12 Protein, Research Grade
- タンパク質名
- IL-12B & IL-12A
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries no "tag". The protein has a calculated MW of 58.9 kDa. The protein migrates as 76 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 0.01 EU per μg |
| Purity | 95% |
| Description | IL-12 is produced by macrophages and B?lymphocytes and has been shown to have multiple effects on T?cells and natural killer?(NK) cells. These effects include inducing production of IFN-gamma and TNF by resting and activated T?and NK?cells, synergizing with other IFN-gamma ?inducers at both the transcriptional and post-transcriptional levels.?This interaction induces IFN-gamma ?gene expression, enhancing the cytotoxic activity of resting NK and T?cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer?(LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T?and NK?cells. Current evidence indicates that IL?12, produced by macrophages in response to infectious agents, is a central mediator of the cell?mediated immune response by its actions on the development, proliferation, and activities of TH1?cells. In its role as the initiator of cell-mediated immunity, it has been suggested that IL-12 has therapeutic potential as a stimulator of cell-mediated immune responses to microbial pathogens, metastatic cancers, and viral infections such as AIDS. |
| Reference | 2609 |
| URL | https://www.acrobiosystems.com/products/protein/il-12b-il-12a-human-il2-h5213 |
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