リコンビナントタンパク質
ACROBiosystems社 プロダクトリスト:Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- IL2-H4210
- 製品名称
- Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag
- タンパク質名
- IL-12B & IL-12A
- Species
- Human
- HOST
- HEK293
Overview
Synonyms | - |
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Characteristics | Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag is produced by co-expression of IL-12B and IL-12A, has a calculated MW of 36.6 kDa (IL-12B) and 23.8 kDa (IL-12A). Subunit IL-12B is fused with polyhistidine tag at the C-terminus and subunit IL-12A is fused with flag tag at the C-terminus. The reducing (R) heterodimer protein migrates as 45 kDa (IL12B) and 38-43 kDa (IL12A) respectively due to glyosylation. |
Endotoxin Level | 1.0 EU per μg |
Purity | 90% |
Description | Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. |
Reference | - |
URL | https://www.acrobiosystems.com/P1583-Human-IL-12BIL-12A-Heterodimer-Protein-His-TagFlag-Tag.html |