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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
IL1-H82F7
製品名称
Biotinylated Human IL-21 Protein, Fc Tag, Avi Tag (Avitag)
タンパク質名
IL-21
Species
Human
HOST
HEK293
25ug: 74,000円
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200ug: 290,000円
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Overview

Synonyms IL21,Za11,Interleukin-21
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag). The protein has a calculated MW of 43.9 kDa. The protein migrates as 36 kDa and 48-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >90% as determined by SDS-PAGE.
Description Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Reference (1) Chtanova T, et al., 2004, J Immunol 173 (1): 68?78.
(2) Wei L, et al., 2007, J Biol Chem 282 (48): 34605?10.
(3) Wurster AL, et al., 2002, J Exp Med 196 (7): 969?77.
(4) Iannello A, et al., 2010, J Leukoc Biol 87 (5): 857?67.
(5) Williams L.D., et al., 2010, Journal of Virology 85 (5): 2316?2324.
URL http://www.acrobiosystems.com/P2370-Biotinylated-Human-IL-21-Protein-Fc-Tag-Avi-Tag.html

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