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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- IGR-H83E3
- 製品名称
- Biotinylated Human IGF-I R / IGF-1 R Protein, His,Avitag? (MALS verified)
- タンパク質名
- IGF-I R / IGF-1 R
- Species
- Human
- HOST
- CHO
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 106.4 kDa. The protein migrates as 35-45 kDa and 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | N/A |
| Purity | 95% |
| Description | The Insulin-like Growth Factor 1 Receptor (IGF1R) is also known as CD221 and JTK13, and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide hormone similar in molecular structure to insulin. IGF1R is made up of two α subunits and two β subunits. Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by disulfide bonds to form a functional transmembrane αβ chain. The α chains are located extracellularly, while the β subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R has a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is 60% sequence homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation. |
| Reference | 2541 |
| URL | https://www.acrobiosystems.com/products/protein/igf-i-r-igf-1-r-human-igr-h83e3 |
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