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- サプライヤー
- AcroBioSystems
- カタログNo.
- IG1-H5117
- 製品名称
- Human IGF-I Protein, premium grade
- タンパク質名
- IGF-I
- Species
- Human
- HOST
- E. coli
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries no "tag". The protein has a calculated MW of 7.7 kDa. The protein migrates as 8 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE). |
| Endotoxin Level | 0.01 EU per μg |
| Purity | 95% |
| Description | Insulin-like growth factor 1 (IGF-1 or IGF-I), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C?terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6?kDa mature IGF?1 is identical between isoforms and is generated by proteolytic removal of the N- and C?terminal regions. Mature human IGF-1 shares 94%?and 96% aa sequence identity with mouse and rat IGF-1, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF2. Circulating IGF-1 is produced by hepatocytes, while local IGF-1 is produced by many other tissues in which it has paracrine effects (1). IGF-1 induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-1 regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4?7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-1 binds IGF1R, IGF2R, and the insulin receptor, although its effects are mediated primarily by IGF1R (9). IGF-1 association with IGF binding proteins increases its plasma half?life and modulates its interactions with receptors (10). |
| Reference | 2480 |
| URL | https://www.acrobiosystems.com/products/protein/igf-i-human-ig1-h5117 |
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