ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Human ICAM-1 / CD54 Protein, His Tag
|Characteristics||This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 51.4 kDa. The protein migrates as 60-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>95% as determined by SDS-PAGE.|
|Description||Inter-Cellular Adhesion Molecule 1 (ICAM-1) is also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.|
|Reference||(1) Rothlein, R. D., 1986, Journal of Immunology 137 (4): 1270?1274.
(2) Yang L, et al., 2005, Blood 106 (2): 584?92.
(3) Polin RS, et al., 1998, J. Neurosurg. 89 (4): 559?67.
(4) Frijns CJ, Kappelle LJ., 2002, Stroke 33 (8): 2115?22.