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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- HLT-HA2H7
- 製品名称
- APC-Labeled Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Tetramer Protein
- タンパク質名
- HLA-A*0201 & B2M & hTERT (ILAKFLHWL)
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | APC-Labeled Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Tetramer Protein is assembled by biotinylated monomer and APC-labeled streptavidin. Biotinylated Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Complex Protein is produced by co-expression of HLA and B2M loaded with hTERT peptide. Biotinylated Human HLA-A*02:01&B2M&hTERT (ILAKFLHWL) Complex Protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). |
| Endotoxin Level | N/A |
| Purity | N/A |
| Description | hTERT (human Telomerase Reverse Transcriptase), the catalytic subunit of telomerase, maintains telomere length to drive tumor cells’ unlimited proliferation. It is highly expressed in ~85-90% of cancers but silenced in most normal somatic cells. The peptide ILAKFLHWL (from hTERT residues 540-548) acts as a tumor-specific antigen. It binds to MHC class I molecule HLA-A0201 to form a surface complex on tumors, activating cytotoxic T lymphocytes (CTLs). The Human HLA-A*0201 hTERT (ILAKFLHWL) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M, and ILAKFLHWL peptide of the hTERT. |
| Reference | 2387 |
| URL | https://www.acrobiosystems.com/products/protein/hla-a-0201-b2m-htert-ilakflhwl-human-hlt-ha2h7 |
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