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- サプライヤー
- AcroBioSystems
- カタログNo.
- HLN-H82E7
- 製品名称
- Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Complex Protein (Monomer, MALS verified)
- タンパク質名
- HLA-A*0201 & B2M & Survivin (LTLGEFLKL)
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | Biotinylated Human HLA-A*02:01&B2M&Survivin (LTLGEFLKL) Complex Protein is produced by co-expression of HLA and B2M loaded with Survivin peptide. This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 36.3 kDa and 11.7 kDa. The protein migrates as 40-43 kDa and 10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | N/A |
| Purity | 90% |
| Description | The HLA-A*02:01&B2M&Survivin (LTLGEFLKL) complex is a key antigen-presenting complex in the immune system. HLA-A*02:01, a major histocompatibility complex (MHC) class I molecule, forms a stable heterodimer with β2-microglobulin (B2M). Subsequently, this dimer binds to the Survivin-derived peptide LTLGEFLKL?a specific epitope of Survivin, an anti-apoptotic protein overexpressed in various tumors. This complex is critical for activating cytotoxic T lymphocytes (CTLs), enabling the immune system to recognize and eliminate tumor cells expressing Survivin. |
| Reference | 2339 |
| URL | https://www.acrobiosystems.com/products/protein/hla-a-0201-b2m-survivin-ltlgeflkl-human-hln-h82e7 |
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