Biotinylated Human HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Complex Protein (Monomer, MALS verified) [HLE-H82E8]

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サプライヤー: AcroBioSystems
カタログNo.: HLE-H82E8
製品名称: Biotinylated Human HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Complex Protein (Monomer, MALS verified)
タンパク質名: HLA-A*0201 & B2M & PRAME (SLLQHLIGL)
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	Biotinylated Human HLA-A*02:01&B2M&PRAME (SLLQHLIGL) Complex Protein is produced by co-expression of HLA and B2M loaded with PRAME peptide. This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 51.3 kDa. The protein migrates as 58-61 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	95%
Description	This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. The PRAME (SLLQHLIGL) was shown to be recognized by HLA-A0201 tumor-infiltrating lymphocytes from melanoma patients, and therefore it is widely been studied in TCR-T studies. The Human HLA-A0201 PRAME (SLLQHLIGL) complex protein is a complex of HLA-A*0201 of?the MHC Class I, B2M and PRAME (SLLQHLIGL) peptide.
Reference	2280
URL	https://www.acrobiosystems.com/products/protein/hla-a-0201-b2m-prame-sllqhligl-human-hle-h82e8

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