Biotinylated Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Complex Protein (Monomer, MALS verified) [HLE-H82E6]

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サプライヤー: AcroBioSystems
カタログNo.: HLE-H82E6
製品名称: Biotinylated Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Complex Protein (Monomer, MALS verified)
タンパク質名: HLA-A*0201 & B2M & PRAME (ALYVDSLFFL)
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	Biotinylated Human HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Complex Protein is produced by co-expression of HLA and B2M loaded with PRAME peptide. This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 36.3 kDa and 11.7 kDa. The protein migrates as 40-43 kDa and 10 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	90%
Description	PRAME (Preferentially Expressed Antigen in Melanoma) is a well-characterized member of the cancer/testis antigen family. Functioning as a nuclear receptor and transcriptional regulator, PRAME negatively modulates retinoic acid signaling, thereby regulating tumor cell differentiation and proliferation. It is aberrantly overexpressed in a variety of malignancies, especially cutaneous melanoma, and its upregulation is closely linked to aggressive tumor phenotypes. Given its tumor-specific expression and oncogenic role, PRAME has emerged as a promising diagnostic biomarker, prognostic indicator, and attractive therapeutic target for tumor immunotherapy.
Reference	2279
URL	https://www.acrobiosystems.com/products/protein/hla-a-0201-b2m-prame-alyvdslffl-human-hle-h82e6

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