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- サプライヤー
- AcroBioSystems
- カタログNo.
- GZB-H5213
- 製品名称
- Human Granzyme B Protein, Tag Free (active enzyme)
- タンパク質名
- Granzyme B
- Species
- Human
- HOST
- HEK293
- 20ug: 74,000円
- お問い合わせ
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries no "tag". The protein has a calculated MW of 25.5 kDa . The protein migrates as 34-37 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | Granzyme B (GZMB) is a cytosolic protease abundant in cytotoxic T-cells and natural killer cells, pivotal for immune defense. Delivered into target cells, GZMB activates caspase-independent pyroptosis by cleaving gasdermin-E (GSDME). This triggers pyroptosis, leading to target cell death. GZMB exhibits substrate specificity for aspartate residue cleavage and contributes to an activation cascade of caspases, impacting apoptosis execution. Involved in bacterial infection response, GZMB cleaves and activates caspase-7, promoting plasma membrane repair. Its multifaceted activities underscore its crucial role in immune responses and cellular defense. |
| Reference | - |
| URL | N/A |
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