Human CTGF / CCN2 Protein, Fc Tag [GTF-H5253]

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Synonyms	-
Characteristics	This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 61.9 kDa. The protein migrates as 48-53 kDa and 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/ctgf-human-gtf-h5253

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