Human gp130 & OSMR Heterodimer Protein, His Tag (MALS verified) [GPR-H52H3]

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Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 151.8 kDa. The protein migrates as 170-230 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	OSM signaling on responsive cells is mediated by binding to two distinct signaling receptor complexes identified as type I and type II OSM receptors. Type II OSM receptor (gp130/OSMRβ) is a heterodimer composed of gp130 and OSM receptor β subunit. The type II receptor has OSM specificity. This receptor triggers the activation of associated Janus kinases (JAKs), leading primarily to the phosphorylation and activation of the Signal Transducer and Activator of Transcription 3 (STAT3) pathway.
Reference	2059
URL	https://www.acrobiosystems.com/products/protein/gp130-osmr-human-gpr-h52h3

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