HHV-5 (strain AD169) gH&gL&gO, Twin-Strep Tag&Tag Free&His Tag [GLO-H5283]

Synonyms	-
Characteristics	This protein carries a twin strep tag at the C-terminus. The protein has a calculated MW of 82.6 kDa \| 27.6 kDa \| 52.6 kDa. The protein migrates as 33 kDa,120-160 kDa and >180 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.
Reference	-
URL	https://www.acrobiosystems.com/P7123-HHV-5-%28strain-AD169%29-gHgLgO-Twin-Strep-TagTag-FreeHis-Tag.html

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