Human GAD1 / GAD67 Protein, His Tag [GA1-H5543]

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Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 68.8 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	85%
Description	Glutamate?decarboxylase?or?glutamic?acid?decarboxylase?(GAD)?is?an?enzyme?that?catalyzes?the?decarboxylation?of?glutamate?to?gamma-aminobutyric?acid?(GABA), the major inhibitory transmitter in higher brain regions, and putative paracrine hormone in pancreatic islets.?GAD?uses?pyridoxal-phosphate?(PLP)?as?a?cofactor.Two molecular forms of GAD (65 kDa and 67 kDa) are highly conserved and both are expressed in the CNS, pancreatic islet cells, testis, oviduct and ovary. The isoforms are regionally distributed cytoplasmically in the brains of rats and mice. GAD65 is an ampiphilic, membrane-anchored protein (585 a.a.), and is responsible for vesicular GABA production. GAD67 is cytoplasmic (594 a.a.), and seems to be responsible for significant cytoplasmic GABA production.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/gad1-human-ga1-h5543

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