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タンパク質カタログ
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- サプライヤー
- AcroBioSystems
- カタログNo.
- FXI-C52H3
- 製品名称
- Rhesus macaque Coagulation factor XI Protein, His Tag (SPR verified)
- タンパク質名
- Coagulation factor XI
- Species
- Rhesus macaque
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 69.8 kDa. The protein migrates as 80-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/coagulation-factor-xi-rhesus-macaque-fxi-c52h3 |
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