Mouse Fc epsilon RI alpha Protein, Fc Tag [FCA-M5253]

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Synonyms	-
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 47.6 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	95%
Description	Fc epsilon RI alpha (FcεRIα) is the α-chain of the high-affinity IgE receptor (FcεRI), a critical mediator of type I hypersensitivity. As a transmembrane glycoprotein in the immunoglobulin superfamily, its extracellular domain specifically binds the Fc region of IgE. Mainly expressed on mast cells and basophils, FcεRIα cross-linking (by IgE-allergen complexes) triggers cell degranulation, releasing histamine and proinflammatory mediators?driving allergies, asthma, and anaphylaxis. It also participates in immune surveillance. Owing to its central role in allergic responses, FcεRIα is a key therapeutic target for anti-allergy agents.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/fc-epsilon-ri-alpha-mouse-fca-m5253

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