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- サプライヤー
- AcroBioSystems
- カタログNo.
- ERR-H5255
- 製品名称
- Human Erythropoietin R & CD131 Protein, Fc Tag&Fc Tag (MALS verified)
- タンパク質名
- Erythropoietin R & CD131
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | Human Erythropoietin R & CD131 Protein, Fc Tag&Fc Tag is produced by co-expression of Erythropoietin R and CD131, has a calculated MW of 51.3 kDa (Erythropoietin R) & 74.9 kDa (CD131). Subunit Erythropoietin R is fused with a human IgG1 Fc tag at the C-terminus and subunit CD131 is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 55-60 kDa and 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 1.0 EU per μg |
| Purity | 90% |
| Description | Epo (Erythropoietin) is the primary regulator of erythropoiesis and is critical for tissue oxygenation under both steady-state conditions and after acute blood loss or hypoxia. The EPO R is the primary receptor that binds to and transmits the activation signal of the EPO cytokine.ERO R is a member of the type I cytokine receptor superfamily. It usually exists as a homodimer and expressed extensively in EPO-responsive BM erythroid progenitors (BFU-E and CFU-E). The interaction of EPO with EPO R at the level of proerythroid cells activates proliferation, increases survival and promotes cell-restricted lineage erythroid differentiation. EPO also binds to the heterodimeric complex EPO-R on non-erythroid tissues (brain, heart, retina, kidney and others). This heterodimeric complex consists of one chain of EPO-R and a ubiquitous colony-stimulating factor 2 receptor β-chain (CD131). This heterodimeric receptor has been called the tissue protective receptor (TPR) of EPO. Although the interaction of EPO with TPR does not initiate erythropoiesis, it signals biochemical cascades (activation of PI3K, MARK, STAT5 and others), leading to the protection of cells from apoptosis, degeneration and cytotoxicity in general. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/erythropoietin-r-cd131-human-err-h5255 |
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