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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
ER2-M5220
製品名称
Mouse Her2 / ErbB2 Protein
タンパク質名
Her2
Species
Mouse
HOST
HEK293
100ug: 74,000円
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1mg: 441,000円
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Overview

Synonyms ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 70.5 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >95% as determined by SDS-PAGE.
Description Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2/neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer,communication at the neuromuscular junction andregulation of cell growth and differentiation.
Reference (1) Kanai, Y. et. al., 1995, Biochem. Biophys. Res. Commun.208:1067.
(2) Codony-Seeervat, J. et al., 1999, Cancer Res. 59: 1196-1201.
(3) Tzahar, E. et al., 1998, Biochim. Biophys. Acta. 1377: 25-37.
(4) Kermit, L. et al, 1999, J. Biol. Chem. 274: 5263-5266.
(5) Hellyer, N.J. et. al., 2001, J. Biol. Chem. 276:42153.
(6) Daly, R.J., 1999, Growth Factors 16:255.
URL https://www.acrobiosystems.com/P389-Mouse-ErbB2-HER2-Protein.html

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