Recombinant Mouse TREM-1 (C-6His) [EPT118] | ナミキ商事株式会社

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サプライヤー: ELK Biotechnology
カタログNo.: EPT118
製品名称: Recombinant Mouse TREM-1 (C-6His)
タンパク質名: 20.9 KDa
Species: -
HOST: Triggering receptor expressed on myeloid cells 1; TREM-1; CD354; Trem1

Synonyms	-
Characteristics	Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) is a transmembrane protein with a single Ig-like domain. TREM-1 associates with the adapter protein, DAP12, to deliver an activating signal. TREM-1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. It stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is amplifier of inflammatory responses that are triggered by bacterial and fungal infections and are a crucial mediator of septic shock.
Endotoxin Level	Less than 0.1 ng/?g (1 EU/?g) as determined by LAL test.
Purity	Greater than 95% as determined by reducing SDS-PAGE.
Description	-
Reference	-
URL	-

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