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- サプライヤー
- ELK Biotechnology
- カタログNo.
- EPT060
- 製品名称
- Recombinant Human CD207 (N-6His)
- タンパク質名
- 31.5 KDa
- Species
- -
- HOST
- CD207 antigen; langerin; CD207; C-type lectin domain family 4 member K
- 50ug: -
- お問い合わせ
Overview
| Synonyms | - |
|---|---|
| Characteristics | Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Human langerin shares 68%, 62%, 71% aa identity with mouse, rat and bovine langerin ECD, respectively. Trimerization greatly increases the lectin binding affinity. Langerin internalizes endogenous proteins such as type I procollagen. Internalization by LC is thought to lead to suppression of self reactions. Langerin also mediates endocytosis of non-peptide antigens containing mannose, N-acetyl glucosamine and fucose that are expressed by mycobacteria and fungae. |
| Endotoxin Level | Less than 0.1 ng/?g (1 EU/?g) as determined by LAL test. |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Description | - |
| Reference | - |
| URL | - |
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