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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
EPM-C5227
製品名称
Rhesus macaque EpCAM / TROP1 Protein
タンパク質名
EpCAM
Species
Rhesus macaque
HOST
HEK293
50ug: 74,000円
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1mg: 416,000円
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Overview

Synonyms EPCAM,TACSTD1,TROP1,CD326,DIAR5,EGP2,EGP314,EGP40,ESA,GA733-2,HNPCC8,HNPCC-8,KS1/4,KSA,M4S1,MIC18,MK1
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.2 kDa. The protein migrates as 28-40 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >95% as determined by SDS-PAGE.
Description EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.
Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
Reference (1) Linnenbach, et al., 1993, Mol Cell Biol 13 (3): 1507?15.
(2) Akita H, et al., 2011, Oncogene.
(3) Winter MJ, et al., 2007, Mol Cell Biochem. 302(1-2):19-26.
(4) Schmidt M, et al., 2011, Breast Cancer Res Treat. 125(3):637-46.
URL https://www.acrobiosystems.com/P623-Rhesus-Macaque-EpCAM-CD326-Protein.html

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