ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Rhesus macaque EpCAM / TROP1 Protein
- Rhesus macaque
|Characteristics||This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.2 kDa. The protein migrates as 28-40 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>95% as determined by SDS-PAGE.|
|Description||EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy.
Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
|Reference||(1) Linnenbach, et al., 1993, Mol Cell Biol 13 (3): 1507?15.
(2) Akita H, et al., 2011, Oncogene.
(3) Winter MJ, et al., 2007, Mol Cell Biochem. 302(1-2):19-26.
(4) Schmidt M, et al., 2011, Breast Cancer Res Treat. 125(3):637-46.