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- サプライヤー
- AcroBioSystems
- カタログNo.
- EP2-H82E4
- 製品名称
- Biotinylated Human EphA2 Protein, His,Avitag? (MALS verified)
- タンパク質名
- EphA2
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 59.8 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | 0.1 EU per μg |
| Purity | 90% |
| Description | EphA2 is a member of the Eph receptor tyrosine kinase family, widely involved in cell adhesion, migration, and tissue boundary formation. It is frequently overexpressed in multiple solid tumors, including breast, lung, ovarian, and pancreatic cancers, where it drives tumor progression, angiogenesis, and metastasis. EphA2 signaling is activated by ephrin?A ligands and contributes to oncogenic pathways such as MAPK and PI3K. Because of its high tumor selectivity and surface accessibility, EphA2 is a prominent therapeutic target for antibodies, ADCs, and CAR?T therapies. |
| Reference | 1555 |
| URL | https://www.acrobiosystems.com/products/protein/epha2-human-ep2-h82e4 |
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