Human CXADR / CAR Protein, His Tag [CXR-H5222]

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Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.9 kDa. The protein migrates as 32-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human?CXADR?protein contains?a?signal?sequence,?a?extracellular?domain?(ECD)?with?a?V? type?(D1)?and?a?C2? type?(D2)?Ig?like?domain,?a? transmembrane?segment?and?a?intracellular?domain.?D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/cxadr-human-cxr-h5222

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