Human Cathepsin B / CTSB (L26V) Protein, Tag Free (Pro-form, MALS verified) [CTB-H5213]

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サプライヤー: AcroBioSystems
カタログNo.: CTB-H5213
製品名称: Human Cathepsin B / CTSB (L26V) Protein, Tag Free (Pro-form, MALS verified)
タンパク質名: Cathepsin B
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	This protein carries no "tag". The protein has a calculated MW of 35.9 kDa. The protein migrates as 30-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Endotoxin Level	N/A
Purity	90%
Description	Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds; Preferentially cleaves -Arg-Arg-\|-Xaa bonds in small molecule substrates (thus differing from cathepsin L); In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.
Reference	1363
URL	https://www.acrobiosystems.com/products/protein/cathepsin-b-human-ctb-h5213

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