ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Mouse IL-17A / CTLA-8 Protein
- 100ug: 89,000円
|Characteristics||This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 15.8 kDa. The protein migrates as 18 kDa, 20-23 kDa and 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>90% as determined by SDS-PAGE.|
|Description||Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.|
|Reference||(1) Yao Z., et al.,1995, J. Immunol. 155:5483-5486.
(2) Gerhardt S., et al., 2009, J. Mol. Biol. 394:905-921.