検索タンパク質（癌免疫療法用）
ACROBiosystems社 プロダクトリスト：Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- CT4-M52H5
- 製品名称
- Mouse CTLA-4 / CD152 Protein
- タンパク質名
- CTLA-4
- Species
- Mouse
- HOST
- HEK293
Overview
| Synonyms | CTLA4,CD152 |
|---|---|
| Characteristics | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | Less than 1.0 EU per μg by the LAL method. |
| Purity | >95% as determined by SDS-PAGE. |
| Description | CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis. |
| Reference | (1) Waterhouse P, et al., 1995, Science 270 (5238): 985?8. (2) Magistrelli G, et al., 1999. Eur. J. Immunol. 29 (11): 3596?602. (3) Rudd, CE. et al., 2009, Immunol. Rev.?229?(1): 12-26. |
| URL | https://www.acrobiosystems.com/P1964-Mouse-CTLA-4--CD152-Protein.html |
お問い合わせリスト