Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin (MALS verified) [CT4-H52A4]

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サプライヤー: AcroBioSystems
カタログNo.: CT4-H52A4
製品名称: Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin (MALS verified)
タンパク質名: CTLA-4
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition.
Endotoxin Level	0.01 EU per μg
Purity	95%
Description	CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/ctla-4-human-ct4-h52a4

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