Human Complement C5 Protein, Fc Tag [CO5-H5253]

Synonyms	-
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 212.8 kDa. The protein migrates as 70 kDa,150 kDa and >180 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Reference	-
URL	https://www.acrobiosystems.com/P6935-Human-Complement-C5-Protein-Fc-Tag.html

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