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- サプライヤー
- AcroBioSystems
- カタログNo.
- CLM-H82Q3
- 製品名称
- Biotinylated Human CLEC4M Protein, Avitag?,His Tag (MALS verified)
- タンパク質名
- CLEC4M
- Species
- Human
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein carries an Avi tag (Avitag?) at the N-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 41.3 kDa. The protein migrates as 42-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level | N/A |
| Purity | 95% |
| Description | CLEC4M encodes a C-type lectin receptor crucially involved in cell adhesion and diverse pathogen recognition. This receptor notably binds a wide array of evolutionarily divergent and clinically significant pathogens, including Mycobacterium tuberculosis, as well as viruses such as Ebola, Hepatitis C (HCV), HIV-1, Influenza A, West Nile virus, and the SARS-CoV acute respiratory syndrome coronavirus. Structurally, the protein is organized into four distinct domains: an N-terminal cytoplasmic domain implicated in internalization, a transmembrane region, a flexible tandem-repeat neck domain of variable length, and a C-terminal carbohydrate recognition domain (CRD). CLEC4M shares close sequence and functional homology with the neighboring gene CD209 (DC-SIGN), though they differ in specific viral recognition profiles and tissue expression patterns. CLEC4M exhibits high expression in the endothelial cells of the liver, lymph node, and placenta, and crucially, polymorphisms within its tandem-repeat neck domain have been associated with resistance to SARS infection. |
| Reference | - |
| URL | https://www.acrobiosystems.com/products/protein/clec4m-human-clm-h82q3 |
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