Biotinylated Human / Cynomolgus Claudin-18.2 Protein, His,Avitag? (Detergent) [CL2-H82E3]

サプライヤー: AcroBioSystems
カタログNo.: CL2-H82E3
製品名称: Biotinylated Human / Cynomolgus Claudin-18.2 Protein, His,Avitag? (Detergent)
タンパク質名: Claudin-18.2
Species: Human / Cynomolgus
HOST: InsectCells

Synonyms	-
Characteristics	This protein carries an Avi tag at the N-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 24.8 kDa. <br><strong>It is produced as active membrane protein with full ECD epitopes, and contains both the ECL1 and ECL2.</strong>
Endotoxin Level	1.0 EU per μg
Purity	60%
Description	Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Reference	-
URL	https://www.acrobiosystems.com/P3759-Biotinylated-Human--Cynomolgus-Claudin-182-Protein-HisAvitag%E2%84%A2-%28Detergent%29.html

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