ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Cynomolgus LILRB4 / CD85k / ILT3 Protein, Fc Tag
- 100ug: 95,000円
|Characteristics||This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.7 kDa. As a result of glycosylation, the protein migrates as 60-66 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-P|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>85% as determined by SDS-PAGE.|
|Description||Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.|
|Reference||(1) Cella M., et al., 1997, J. Exp. Med. 185:1743-1751.
(2) Chang C.C., et al., 2002, Nat. Immunol. 3:237-243.