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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
CDK-C5227
製品名称
Cynomolgus LILRB4 / CD85k / ILT3 Protein, His Tag
タンパク質名
LILRB4
Species
Cynomolgus
HOST
HEK293
100ug: 95,000円
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Overview

Synonyms LILRB4,ILT3,LIR5,CD85K,HM18
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.0 kDa. The protein migrates as 38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >90% as determined by SDS-PAGE.
Description Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Reference (1) Cella M., et al., 1997, J. Exp. Med. 185:1743-1751.
(2) Chang C.C., et al., 2002, Nat. Immunol. 3:237-243.
URL https://www.acrobiosystems.com/P2357-Cynomolgus-LILRB4--CD85k--ILT3-Protein-His-Tag.html

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