リコンビナントタンパク質
ACROBiosystems社 プロダクトリスト:Recombinant Protein
- サプライヤー
- AcroBioSystems
- カタログNo.
- CDB-C82E4
- 製品名称
- Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His,Avitag? (SPR & BLI & MALS verified)
- タンパク質名
- Fc gamma RIIB / CD32b
- Species
- Cynomolgus
- HOST
- HEK293
Overview
Synonyms | - |
---|---|
Characteristics | This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 23.6 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin Level | 1.0 EU per μg |
Purity | 95% |
Description | Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies. |
Reference | - |
URL | https://www.acrobiosystems.com/P2846-Biotinylated-Cynomolgus-Fc-gamma-RIIB--CD32b-Protein-HisAvitag%E2%84%A2-%28SPR--BLI--MALS-verified%29.html |