Mouse CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His Tag&Tag Free (MALS verified) [CDA-M52W3]

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サプライヤー: AcroBioSystems
カタログNo.: CDA-M52W3
製品名称: Mouse CD8 alpha&beta (CD8A&CD8B) Heterodimer Protein, His Tag&Tag Free (MALS verified)
タンパク質名: CD8 alpha & beta
Species: Mouse
HOST: HEK293

Synonyms	-
Characteristics	Mouse CD8A&CD8B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of CD8 alpha and CD8 beta, has a calculated MW of 24.9 kDa (CD8 alpha) and 21.9 kDa (CD8 beta). Subunit CD8 alpha is fused with with a polyhistidine tag at the C-terminus and subunit CD8 beta contains no tag. The protein migrates as 30-33 kDa and 39-42 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	95%
Description	The CD8αβ heterodimer is a key cell surface co-receptor on cytotoxic T lymphocytes. It binds to MHC class I molecules on antigen-presenting cells, stabilizing the interaction between the T-cell receptor (TCR) and the peptide-MHC complex. This binding is essential for T-cell activation, positive selection in the thymus, and the effector function of mature CD8+ T cells. The β-chain (CD8β) modulates the affinity of the interaction, contributes to signal transduction, and promotes the stable surface expression of the heterodimer.
Reference	1004
URL	https://www.acrobiosystems.com/products/protein/cd8-alpha-beta-mouse-cda-m52w3

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