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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
CDA-M52H8
製品名称
Mouse FCGR3A / CD16a Protein
タンパク質名
Fc gamma RIIIA / CD16a
Species
Mouse
HOST
HEK293
100ug: 59,000円
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Overview

Synonyms FCGR3A,CD16A,FCG3,FCGR3,IGFR3
Characteristics This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.95 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >95% as determined by reduced SDS-PAGE.
Description CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.
CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody?dependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
Reference (1) Webster NL., et al., 2006, J Leukoc Biol. 79: 294-302.
(2) Nagarajan S., et al., 1995, J Biol Chem. 270: 25762-70.
(3) Ravetch JV., 1989, J.?Exp.?Med.?170:481.
URL https://www.acrobiosystems.com/P2042-Mouse-FCGR3A--CD16a-Protein.html

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