ACROBiosystems社 プロダクトリスト：Recombinant Protein
- Biotinylated Human LILRB3 / CD85a / ILT5 Protein, Fc Tag, Avi Tag (Avitag)
|Characteristics||This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag). The protein has a calculated MW of 74.5 kDa. As a result of glycosylation, the protein migrates as 80-105 kDa under reducing (R) condition, and 150 kDa under non-reducing (NR) condition (SDS-PAGE).|
|Endotoxin Level||Less than 1.0 EU per μg by the LAL method.|
|Purity||>95% as determined by SDS-PAGE.|
|Description||Leukocyte immunoglobulin-like receptor subfamily B member 3 is also known as LILRB3,ILT-5 or CD85a. LILRB3 plays an role as receptor for class I MHC antigens, which activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. LILRB3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through association with an activating adaptor molecule, FcRγ.|
|Reference||(1) Bashirova AA., et al., 2014, Immunogenetics.66(1):1-8.
(2) Huang J., et al., 2010, J Virol. 84(18):9463-9471. (3) Pfistershammer K., et al., 2009, Blood. 114(11):2323-2332.