Rhesus macaque CD89 / FCAR Protein, His Tag (MALS verified) [CD9-R52H5]

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Synonyms	-
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 25.2 kDa. The protein migrates as 45-58 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	1.0 EU per μg
Purity	90%
Description	CD89 (FcαRI), encoded by the FCAR gene, is an IgA-specific receptor primarily expressed on myeloid cells (e.g., neutrophils, monocytes/macrophages). It mediates immune defense functions by binding to the Fc region of IgA (with a preference for polymeric forms), facilitating phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and inflammation regulation. Its signaling relies on the ITAM motif of the FcRγ chain, enabling dual immunoregulatory roles in both activation and suppression. Clinically, CD89 is implicated in IgA nephropathy, pathogen immune evasion, and tumor immunity. Targeted therapies, such as the bispecific antibody MOR202, are under development for diseases like multiple myeloma, highlighting its therapeutic potential as a bridge between mucosal and systemic immunity.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/cd89-rhesus-macaque-cd9-r52h5

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