Biotinylated Human CD6 / TP120 Protein, Fc,Avitag? (MALS verified) [CD6-H82F3]

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Synonyms	-
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 68.7 kDa. The protein migrates as 90-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	90%
Description	CD6 is a type 1 transmembrane glycoprotein with three extracellular SRCR domains that functions as a co-stimulatory receptor in T cell activation. Its primary ligand is CD166 (ALCAM), an IgSF member expressed on antigen-presenting cells and other tissues. CD6's long cytoplasmic tail contains tyrosine residues that, upon phosphorylation, recruit signaling molecules like SLP76 and SHP1. The CD6-ALCAM interaction promotes T cell activation and downstream MAPK signaling, influencing proliferation, differentiation, and survival. Importantly, CD6 regulates effector T cell (Teff) activity and trafficking, making it a key checkpoint in autoimmunity. Blocking the CD6-ALCAM pathway selectively inhibits pathogenic Teff cells while preserving Treg function, offering a potential therapeutic strategy for autoimmune diseases.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/cd6-human-cd6-h82f3

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