| Synonyms |
- |
| Characteristics |
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 42.2 kDa. The protein migrates as 50-55 kDa under reducing (R) condition, and 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation. |
| Endotoxin Level |
0.01 EU per μg |
| Purity |
95% |
| Description |
T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules. |
| Reference |
- |
| URL |
https://www.acrobiosystems.com/P3572-Biotinylated-Human-CD5-Protein-HisAvitag%E2%84%A2-premium-grade.html |
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