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タンパク質(癌免疫療法用)

ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
CD4-C5256
製品名称
Rhesus macaque CD4 Protein, Fc Tag
タンパク質名
CD4
Species
Rhesus macaque
HOST
HEK293
100ug: 53,000円
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Overview

Synonyms CD4,CD4mut,LEU3
Characteristics This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 67 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Purity >95% as determined by SDS-PAGE.
Description T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
Reference (1) Brady RL, et al., 1993, Science 260 (5110): 979?83.
(2) Zeitlmann, L., et al., 2001, J. Biol. Chem. (United States) 276 (12): 9123?32.
(3) Rudd CE, et al., 2010, J. Immunol. 185 (5): 2645?9.
(4) Rudd CE, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (14): 5190?4.
(5) Gorska MM, et al., 2004, J. Exp. Med. 199 (3): 369?79.
URL http://www.acrobiosystems.com/P1599-Cynomolgus-CD4-LEU3-ProteinC-Fc-Tag.html

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