Biotinylated Human Siglec-3 / CD33 Protein, Fc,Avitag? (MALS verified) [CD3-H82F3]

サプライヤー: AcroBioSystems
カタログNo.: CD3-H82F3
製品名称: Biotinylated Human Siglec-3 / CD33 Protein, Fc,Avitag? (MALS verified)
タンパク質名: Siglec-3
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag?). The protein has a calculated MW of 54.9 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	0.1 EU per μg
Purity	95%
Description	Myeloid?cell?surface?antigen CD33 is also known as SIGLEC3, Siglecs?(sialic?acid?binding?Ig?like?lectins) and?GP67, is a single-pass type I membrane protein which belongs to the?immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-?terminal Ig-?like V?-type domain, one Ig?-like C2-?type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
Reference	-
URL	https://www.acrobiosystems.com/P4164-Biotinylated-Human-Siglec-3--CD33-Protein-FcAvitag%E2%84%A2-%28MALS-verified%29.html

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