Biotinylated Human Siglec-3 / CD33 (G69R) Protein, Avitag?,His Tag (MALS verified) [CD3-H82E9]

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サプライヤー: AcroBioSystems
カタログNo.: CD3-H82E9
製品名称: Biotinylated Human Siglec-3 / CD33 (G69R) Protein, Avitag?,His Tag (MALS verified)
タンパク質名: Siglec-3
Species: Human
HOST: HEK293

Synonyms	-
Characteristics	This protein carries an Avi tag (Avitag?) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 30.4 kDa. The protein migrates as 40-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	N/A
Purity	95%
Description	Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig?like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-?terminal Ig-?like V?-type domain, one Ig?-like C2-?type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/siglec-3-human-cd3-h82e9

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