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ACROBiosystems社 プロダクトリスト:Recombinant Protein

サプライヤー
AcroBioSystems
カタログNo.
CD3-H82E7
製品名称
Biotinylated Human Siglec-3 / CD33 Protein, Avitag?,His Tag (MALS verified)
タンパク質名
Siglec-3
Species
Human
HOST
HEK293
200ug: 302400円
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25ug: 93800円
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Overview

Synonyms -
Characteristics This protein carries an Avi tag (Avitag?) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 29.4 kDa. The protein migrates as 45-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level 0.1 EU per μg
Purity 95%
Description Myeloid?cell?surface?antigen CD33 is also known as SIGLEC3, Siglecs?(sialic?acid?binding?Ig?like?lectins) and?GP67, is a single-pass type I membrane protein which belongs to the?immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-?terminal Ig-?like V?-type domain, one Ig?-like C2-?type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
Reference -
URL https://www.acrobiosystems.com/P2181-Biotinylated-Human-Siglec-3--CD33-Protein-Avitag%E2%84%A2His-Tag-%28MALS-verified%29.html

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