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- サプライヤー
- AcroBioSystems
- カタログNo.
- CC8-R52P3
- 製品名称
- Rhesus macaque CCR8 Full Length Protein (VLP)
- タンパク質名
- CCR8
- Species
- Rhesus macaque
- HOST
- HEK293
Overview
| Synonyms | - |
|---|---|
| Characteristics | This protein . |
| Endotoxin Level | 1.0 EU per μg |
| Purity | N/A |
| Description | CCR8 is a key chemokine receptor primarily expressed on regulatory T cells (Tregs) infiltrating the tumor microenvironment. It plays a decisive role in mediating immunosuppression by facilitating Treg recruitment and activation. Emerging research highlights the interaction between CCR8 and glycosaminoglycans (GAGs), which serve as essential co-receptors. GAGs facilitate the presentation of ligands like CCL1 to CCR8, effectively concentrating chemokines on the cell surface to enhance signaling efficiency. Targeting the CCR8-GAG axis represents a sophisticated strategy for selective Treg depletion, offering high precision for cancer immunotherapy while minimizing systemic autoimmune side effects. |
| Reference | 541 |
| URL | https://www.acrobiosystems.com/products/protein/ccr8-rhesus-macaque-cc8-r52p3 |
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