Human BAFFR / TNFRSF13C Protein, Llama IgG2b Fc Tag, low endotoxin [BAR-H5258]

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Synonyms	-
Characteristics	This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 34.4 kDa. The protein migrates as 42-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level	0.01 EU per μg
Purity	90%
Description	BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
Reference	-
URL	https://www.acrobiosystems.com/products/protein/baffr-human-bar-h5258

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